The Netherlands take on Spain in a high-profile friendly at the Johan Cruijff Arena in Amsterdam on Wednesday evening, report agencies.
Spain suffered a surprise 1-0 loss to Ukraine last time out, while the hosts enter this fixture winless in four matches.
The Netherlands would have entered this year's European Championship finals among the favourites had they gone ahead as planned, but instead they are in a bit of a crisis.
That is by their high standards, at least, having seen head coach Ronald Koeman jump ship to Barcelona and replacement Frank de Boer start his reign with a three-game winless run.
Add the long-term absence of influential defender Virgil van Dijk to the mix and it is clear to see why the mood has been so low around the Dutch camp. De Boer's men find themselves third in Nations League Group A1, two points behind leaders Poland, whom they take on next week.
Before that is a home match with Bosnia-Herzegovina and this visit of Spain, who are also in need of a pick-me-up on the back of an underwhelming October.
Luis Enrique's side drew 0-0 with Portugal and lost 1-0 to Ukraine, either side of edging out Switzerland through a solitary strike from Mikel Oyarzabal.
One goal from three matches is a little worrying for La Roja and something Enrique will be looking to put right, starting with this trip to the Dutch capital. Spain's priority will be the upcoming Nations League Group A4 games with Switzerland and Germany, however, with the 2010 World Cup winners one point clear at the top.
This will be the first meeting between the two European giants since a friendly five years ago, which Spain won 2-0.
Marcos Llorente has been included in Spain's senior squad for the first time, while Alvaro Morata and Koke are back involved following a recent absence.Given his side's lack of goals of late, Enrique may opt to give Llorente - now used further forward - and Morata a chance to shine in Amsterdam.
Rodrigo Moreno is absent from the squad after contracting coronavirus, as is the injured Thiago Alcantara.
Elsewhere, Hector Bellerin was added to the squad on Saturday following Jesus Navas's withdrawal, while Ansu Fati is another who has dropped out of the initial squad.
As for the Netherlands, Ajax star Davy Klaassen is back involved and may earn his first cap since October 2017.
Krasnodar midfielder Tonny Vilhena and Crystal Palace left-back Patrick van Aanholt are also back involved.
With the Nations League taking priority, this might be the game for certain fringe players to be given a run out.
