First meets worst in UEFA Champions League Group F on Tuesday evening, as section leaders Paris Saint-Germain travel to San Siro to meet winless AC Milan.
Les Parisiens took control of the close-knit group with a 3-0 crushing of the Rossoneri two weeks ago, leaving their hosts at risk of a premature exit from European football entirely.
Not the first team to succumb to a Warren Zaire-Emery masterclass this season, AC Milan were run ragged by the highly-rated 17-year-old when they butted heads with PSG a fortnight ago, as Kylian Mbappe and Lee Kang-in both benefitted from assists from the talented teenager on the evening.
Making amends for their 4-1 humiliation at the hands of Newcastle United, PSG - who also have a two-goal success against Dortmund to their name - can officially eliminate Milan from top-spot contention by repeating their previous success over the off-colour Italian troops, and the form book weighs heavily in the visitors' favour.
Milan's downturn in form has coincided with a hefty injury list, as defender Pierre Kalulu has been ruled out for four months following an operation on a tendon injury, while fellow centre-back Simon Kjaer also missed the Udinese loss with a muscular concern.
Marco Pellegrino (heel), Marco Sportiello (calf), Ismael Bennacer (knee) and Mattia Caldara (ankle) are also out of action for the ravaged Rossoneri, who additionally had to make do without Theo Hernandez at the weekend after the Frenchman sustained bruising to his ankle.
Pioli is hopeful that Hernandez will be able to shake off his affliction in time for Tuesday's contest, while Samuel Chukwueze and Christian Pulisic could also make their comebacks here following precautionary rests over the weekend.
PSG were also hit with a fresh defensive blow before taking on Montpellier, as Danilo Pereira was revealed to have suffered a hamstring injury, which will keep the versatile Portuguese sidelined until the conclusion of November's international break.
Nuno Mendes (hamstring), Sergio Rico (head trauma) and PresnelKimpembe (Achilles) will not be making their comebacks just yet either, while Marco Asensio's foot injury and Keylor Navas's back concern should also keep both men unavailable for the time being.
Nordi Mukiele was a surprise inclusion at left-back last time out, but Lucas Hernandez ought to return to an otherwise unaltered XI ahead of a potential reunion with his Rossoneri-clad brother.