Bournemouth will be the latest team to attempt to stop the Liverpool juggernaut when Jurgen Klopp's runaway Premier League leaders visit the Vitality Stadium on Saturday afternoon.
Tottenham Hotspur and Burnley will be looking to recover from poor results during the week when the two sides meet in the Premier League on Saturday.
Liverpool will welcome Alisson back from his one-match ban following his red card against Brighton & Hove Albion, with Adrian set to return to the bench. The Brazilian could be one of a number of changes after Klopp made five against Everton as the likes of Salah, who scored a hat-trick away at Bournemouth last season, Firmino, Henderson and Alex Oxlade-Chamberlain push for recalls.
December is very much the season for giving players a chance, though, and Naby Keita will be hopeful of playing some role while Origi, Shaqiri and Lallana will justifiably expect to have done enough to remain in and around the first team. With a crucial Champions League showdown against Red Bull Salzburg to come next week Klopp may even decide that it is Mane's turn to rest, despite the world's fourth-best player enjoying arguably the most productive spell of his career at the moment.
Fabinho and Joel Matip remain sidelined for the Reds, and Joe Gomez may benefit from any rotation in the absence of the latter. Bournemouth, meanwhile, have a lengthy injury list which has certainly not helped their cause in recent weeks.
Adam Smith became the latest in the crowded treatment room after picking up a knock against Crystal Palace on Tuesday night, leaving him as a major doubt for this match.
The Cherries will also be without Harry Wilson, who is ineligible to face his parent club, while Junior Stanislas, Charlie Daniels and David Brooks are all sidelined. A number of players are in contention to return against the Reds, including Steve Cook, Joshua King, Andrew Surman and Lloyd Kelly, but Howe could also be without the quartet once again.
Ex-Liverpool man Dominic Solanke may have a point to prove against his former club, though, while Ryan Fraser is expected to come back into the side having been heavily linked with a move to Saturday's opponents in the future.
