Simone Inzaghi takes defending Serie A champions Inter Milan to former club Lazio this weekend, while Jose Mourinho's Roma travel to a resurgent Juventus who are hoping to climb back into title contention.
Free-scoring Inter, unbeaten through seven matches with five wins and two draws, have plundered a league-high 22 goals -- the club's best return at this stage of a season since 1950-51.
But the late return of Argentina duo Lautaro Martinez and Joaquin Correa from Thursday's World Cup qualifier against Peru in Buenos Aires could leave Inzaghi without two key attackers.
Lazio supporters are preparing a warm reception for the man who led them to an Italian Cup and back into the Champions League last season for the first time in 13 years, despite the divisive nature of his exit.
Inzaghi, who played for Lazio between 1999 and 2010, ended a 22-year affiliation with the Roman club when he turned down a contract extension to accept the challenge of replacing Antonio Conte at Inter. As part of the coaching merry-go-round this summer which saw 12 managerial changes in Serie A, Maurizio Sarri was chosen as the successor to Inzaghi.
Lazio began the new campaign with back-to-back victories but have won just one in five tries since, defeating Mourinho's Roma in the Derby della Capitale.
They are aiming to avoid successive league defeats for the first time since March and could have Ciro Immobile available again after injury. The Lazio captain has six goals in six matches.
After going four games without a win, Massimiliano Allegri's Juventus have picked up maximum points over the past three matches to surge up the table. Juve host Roma looking for successive victories over the Giallorossi for the first time since 2016. Roma have battled inconsistency following three straight wins to launch their campaign.