Inter Milan laid down an early title marker on Saturday by handing out a 5-1 derby hammering to AC Milan and going it alone at the Serie A summit.
Milan sit a further point back in third after a humiliating first defeat of the season before they welcome Newcastle United in the Champions League on Tuesday.
Spurred on by the majority of a heaving and raucous San Siro crowd, Inter claimed their fifth straight derby win in all competitions thanks to a Henrikh Mkhitaryan brace, Marcus Thuram's rocket and two late strikes from Hakan Calhanoglu and Davide Frattesi.
Simone Inzaghi's side claimed the points with a display which showed why they got past Milan to reach last season's Champions League final and confirmed their status as early favourites to beat their local rivals to a 20th Scudetto.
"We've started the season brilliantly and we want to keep going," Mkhitaryan told DAZN.
"We're all here for the same goal, and I don't care who plays... the coach will pick whoever gives their all for the second star (on the shirt for 20 titles)." Thuram continued his fast start in an Inter shirt, the new man also crucial to Mkhitaryan's fifth-minute opener. And Thuram then underlined Inter's superiority seven minutes before the break after a lightning breakaway started by Lautaro Martinez, collecting from Denzel Dumfries before cutting inside the hapless Thiaw and crashing in an unstoppable shot from the edge of the area.
The match looked dead and buried with 45 minutes to play but Rafael Leao halved the deficit in the 57th minute when he rolled in his second of the season after being brilliantly put through by Olivier Giroud.
Leao's finish was the first goal conceded by Inter this term and as a violent downpour descended on the San Siro, Mkhitaryan silenced Milan's loud "away" support with his deflected second of the evening after being fed by Martinez.
Calhanoglu's 79th-minute penalty and a neat stoppage-time finish from Frattesi, fresh from Tuesday's double for Italy at the same ground, rubbed salt into wounds for Milan and coach Stefano Pioli.