Bayern Munich and Tottenham Hotspur square off at the Allianz Arena on Wednesday night with both clubs having already secured their place in the Champions League knockout stages, report agencies.
With Bayern having guaranteed top spot in Group B, Hans Flick and Jose Mourinho are expected to name much-changed starting lineups for the game in Germany
When Flick extended his winning streak to four matches with a 6-0 demolition of Red Star Belgrade on matchday five, the caretaker boss would have fancied his chances of remaining in the Bayern hotseat until at least the end of the season.
Nevertheless, there will inevitably be concerns over the Bavarians losing their reputation as the top team in Germany at a time when none of their rivals is putting distance between themselves and the rest of the pack.
Robert Lewandowski's free-scoring run has come to a halt at the wrong time, with the Poland international failing to net in each of the last two games.
However, with none of his teammates adding more than four goals in the Bundesliga, the club's leading marksman may feel that it is time that contributions start to come from other areas of the pitch.
The game on Wednesday night is an opportunity for some of the players in question to prove that they are ready to step up to the mark, and a strong performance against their English opponents may earn a spot in the team for the meeting with Werder Bremen at the weekend.
Spurs began this year's European campaign by picking up just one point from fixtures against Olympiacos and Bayern, which subsequently played a significant part in a lack of faith being shown in Mauricio Pochettino.
However, while much has been made of Spurs generally performing below-par this season, the North London side have now suffered just three defeats in 12 matches since losing 7-2 to Bayern in front of their own supporters.
Two of those setbacks came by 2-1 scorelines at Liverpool and Manchester United respectively, suggesting that some context has been lost regarding the current state of affairs at the club.
Since Mourinho was given a place in the dugout, 16 goals have been scored in all competitions, including five which came against Burnley on Saturday afternoon.
However, the biggest plus point for the Portuguese was the clean sheet which was kept versus the Clarets, a shutout which followed four games in which they had shipped a total of eight goals.
Mourinho has already acknowledged that he plans to rest several of his key men for the trip to Germany, something which may prove beneficial given the threat which Bayern offer in attack.
Nevertheless, ahead of important Premier League clashes with Wolverhampton Wanderers and Chelsea, whoever comes into the team will be expected to maintain the momentum which is continuing to build under Mourinho's guidance.
Harry Kane will not feature on Wednesday night, meaning that Troy Parrott is in contention to make his first European start for Spurs.
Mourinho has indicated that the likes of Kyle Walker-Peters, Oliver Skipp and Ryan Sessegnon will all be handed outings at the Allianz Arena.
Toby Alderweireld, Dele Alli and Son Heung-min could be among the players who do not feature on Wednesday night.
Despite being withdrawn against Monchengladbach, Jerome Boateng and Corentin Tolisso are expected to be available for Bayern.
Having remained as unused substitutes for that game, Benjamin Pavard, Philippe Coutinho and Serge Gnabry should all come into the team.
Ahead of serving a domestic suspension at the weekend, Javi Martinez is also likely to start for the home side.
