Israel's foreign ministry says a hospital in Beersheba has been directly hit after Iran fired a wave of missiles.
In Iran, Israel has warned people to evacuate from areas near the Arak heavy water reactor, warning it would target "military infrastructure.
"Sirens sounded in Israel overnight and people have since been told they can leave where they were told to take cover.
The strikes come as Donald Trump has approved plans to attack Iran, but has not made a final decision on whether to strike the country, reports the BBC's US partner CBS.
Earlier, Trump said "I may do it, I may not do it", when asked whether the US would join Israeli strikes on Iran.
Iran's supreme leader warned Trump of "irreparable harm" if the US intervenes.
AP, DUBAI: Israel has attacked Iran’s Arak heavy water reactor, Iranian state television said Thursday.
The report said there was “no radiation danger whatsoever” and that the facility had already been evacuated before the attack.
Israel warned earlier Thursday morning it would attack the facility and urged the public to flee the area.
THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below.
DUBAI, United Arab Emirates (AP) — Israel’s military warned people Thursday to evacuate the area around Iran’s Arak heavy water reactor.
The warning came in a social media post on X. It included a satellite image of the plant in a red circle like other warnings that preceded strikes.
The Israeli military said Thursday’s round of airstrikes targeted Tehran and other areas of Iran, without elaborating. It later said Iran fired a new salvo of missiles at Israel and told the public to take shelter.