Pakistan halted England with three wickets in six balls to take a sensational three-run win in the last over of the fourth Twenty20 international in Karachi on Sunday.
Haris Rauf grabbed three wickets as the hosts tied the seven-match series.
Earlier in-form opener Mohammad Rizwan struck a brilliant 88 as Pakistan made 166-4.
With England needing five for victory from 10 balls, Rauf dismissed Liam Dawson (34) and Olly Stone off successive deliveries in the 19th over.
Last man Reece Topley was then run out as Pakistan rescued victory from almost certain defeat at a packed National stadium in Karachi.
Dawson had silenced a 32,000 holiday crowd by cracking four fours and a six off pacer Mohammad Hasnain's 18th over. When Topley was run out off the second ball of the last over it sent Pakistan players and home fans into raptures.
The win made the occasion of Pakistan's 200th T20I more memorable. They are the first team to reach the milestone. England were rocked by Hasnain (2-40) and Nawaz (3-35) and were staring at defeat at 130-7 before Dawson added 32 with Adil Rashid (three not out) to bring England back in the game. But Rauf's two wickets, he finished 3-32, sealed the match for Pakistan.
The remaining matches are in Lahore (September 28, 30 and October 2). England, who are on their first tour of Pakistan for 17 years, won the first and third games while the home team won the second and fourth -- all in Karachi. Rauf said he was happy to turn the tables on England.
"I had the plan to bowl to Dawson because he was the key wicket for us," said Rauf.
"The crowd was backing me and that pumped me up, it's a great win."
England skipper Moeen Ali showed disappointment.
"It was an amazing game of cricket," said Ali.
"We felt like we should have chased that down, disappointed that we didn't. Pressure happens, and they bowled really well."